Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | FASN | P49327 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | WNT3A | P56704 | 4/20 | 0.31 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737212 | 0.87 | SIGMAR1 (0.39) | SIGMAR1OPRM1CYP2C9CYP3A4LMNA | |
| SCHEMBL737008 | 0.85 | SIGMAR1 (0.42) | SIGMAR1OPRM1FASNCYP2C9CYP3A4 | |
| SCHEMBL736591 | 0.83 | SIGMAR1 (0.48) | SIGMAR1OPRM1LMNAGAAHTT | |
| SCHEMBL737803 | 0.83 | SIGMAR1 (0.47) | SIGMAR1OPRM1CYP2C9CYP3A4LMNA | |
| SCHEMBL738549 | 0.80 | SIGMAR1 (0.40) | SIGMAR1OPRM1 | |
| SCHEMBL737119 | 0.80 | HRH3 (0.47) | SIGMAR1OPRM1CYP3A4GAAALDH1A1 | |
| SCHEMBL735357 | 0.80 | SIGMAR1 (0.61) | SIGMAR1OPRM1CYP2C9LMNAGAA | |
| SCHEMBL736160 | 0.79 | HRH3 (0.41) | — | |
| SCHEMBL737501 | 0.78 | SIGMAR1 (0.45) | SIGMAR1OPRM1FASNGAAHTT | |
| SCHEMBL736347 | 0.77 | SIGMAR1 (0.45) | SIGMAR1OPRM1LMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1892241-A1 | NOVEL PIPERIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-02-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | SIGMAR1 11/4885OPRM1 15/4885FASN 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.