Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 5/20 | 0.61 |
| ▸ | ADRA1A known ✓ | P35348 | 5/20 | 0.61 |
| ▸ | ADRA1B known ✓ | P35368 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 7/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7365878 | 1.00 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7330090 | 0.99 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7330100 | 0.99 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7336580 | 0.92 | DRD2 (0.56) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| Bromide SCHEMBL7357520 | 0.92 | DRD2 (0.66) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| Bromide SCHEMBL7333432 | 0.91 | DRD2 (0.69) | DRD2DRD1DRD3 | |
| Bromide SCHEMBL7333436 | 0.91 | DRD2 (0.69) | DRD2DRD1DRD3 | |
| Bromide SCHEMBL7798984 | 0.91 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| Bromide SCHEMBL7329987 | 0.91 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BDRD2DRD1 | |
| SCHEMBL7333025 | 0.90 | DRD2 (0.54) | ADRA1DADRA1AADRA1BDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |
| EP-0781126-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008228-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1996-03-21 | — | — | WO | disclosed |