Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876282 | 0.84 | REN (0.49) | RENCAPN1CAPN2MMP3MMP1 | |
| SCHEMBL9876531 | 0.84 | REN (0.62) | REN | |
| SCHEMBL10764883 | 0.84 | REN (0.62) | REN | |
| SCHEMBL10460233 | 0.80 | REN (0.63) | REN | |
| SCHEMBL10631292 | 0.79 | REN (0.46) | RENMMP3MMP1MMP2 | |
| SCHEMBL10631298 | 0.79 | REN (0.46) | RENMMP3MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL9876220 | 0.79 | REN (0.46) | RENMMP3MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL9876222 | 0.79 | REN (0.46) | RENMMP3MMP1MMP2 | |
| SCHEMBL9876624 | 0.75 | REN (0.49) | REN | |
| SCHEMBL9874408 | 0.75 | REN (0.49) | RENCAPN1CAPN2MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |