Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876282 | 0.90 | REN (0.49) | RENMMP3MMP1MMP2CTSS | |
| SCHEMBL9876326 | 0.89 | CA1 (0.50) | RENMMP3MMP1MMP2CTSS | |
| SCHEMBL10631298 | 0.88 | REN (0.46) | RENMMP3MMP1MMP2CTSS | |
| SCHEMBL10631292 | 0.88 | REN (0.46) | RENMMP3MMP1MMP2CTSS | |
| Hydrochloric Acid SCHEMBL9876220 | 0.87 | REN (0.46) | RENMMP3MMP1MMP2CTSS | |
| Hydrochloric Acid SCHEMBL9876222 | 0.87 | REN (0.46) | RENMMP3MMP1MMP2CTSS | |
| Hydroxyamine SCHEMBL7357468 | 0.85 | REN (0.53) | RENMMP3CTSSCTSKCTSL | |
| SCHEMBL7300559 | 0.83 | MEN1 (0.52) | RENCTSSCTSKCTSLMETAP2 | |
| SCHEMBL10459436 | 0.82 | REN (0.47) | RENMMP3MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL9876910 | 0.82 | METAP2 (0.52) | RENMMP3MMP1MMP2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |