Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | FLI1 | Q01543 | 1/20 | 0.42 |
| ▸ | EWSR1 | Q01844 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11656990 | 0.95 | HAO1 (0.47) | HAO1NPC1PLK1RAB9AHSD17B3 | |
| SCHEMBL18193726 | 0.89 | HAO1 (0.51) | HAO1NPC1PLK1RAB9AHSD17B3 | |
| SCHEMBL7196791 | 0.87 | L3MBTL1 (0.55) | HAO1NPC1PLK1RAB9AHSD17B3 | |
| SCHEMBL6050822 | 0.81 | GSK3B (0.57) | HAO1PLK1RAB9AMMP2MMP9 | |
| SCHEMBL8536860 | 0.81 | HSD17B3 (0.49) | HAO1NPC1PLK1RAB9AHSD17B3 | |
| SCHEMBL13864138 | 0.81 | HSD17B3 (0.67) | HSD17B3L3MBTL1HTR7LMNAMAPT | |
| SCHEMBL16401383 | 0.81 | HAO1 (0.47) | HAO1NPC1PLK1RAB9AHSD17B3 | |
| SCHEMBL6755453 | 0.79 | HSD17B3 (0.62) | HAO1PLK1HSD17B3L3MBTL1HTR7 | |
| SCHEMBL2237478 | 0.79 | KMT2A (0.60) | NPC1RAB9AHSD17B3L3MBTL1HTR7 | |
| SCHEMBL13398659 | 0.79 | L3MBTL1 (0.52) | NPC1RAB9AL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |