Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | FLI1 | Q01543 | 1/20 | 0.49 |
| ▸ | EWSR1 | Q01844 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18193726 | 0.84 | HAO1 (0.51) | GSK3BHAO1ALDH1A1PLK1MMP2 | |
| SCHEMBL11480265 | 0.82 | GSK3B (0.80) | GSK3BALDH1A1HIF1ATRPA1MAPK1 | |
| SCHEMBL7365891 | 0.81 | HAO1 (0.49) | HAO1PLK1MMP2MMP9MMP8 | |
| SCHEMBL275400 | 0.81 | HAO1 (0.56) | HAO1ALDH1A1PLK1MMP2MMP9 | |
| SCHEMBL6302968 | 0.81 | HAO1 (0.56) | HAO1ALDH1A1PLK1MMP2MMP9 | |
| SCHEMBL11656990 | 0.80 | HAO1 (0.47) | HAO1PLK1MMP2MMP9MMP8 | |
| SCHEMBL456450 | 0.79 | GSK3B (0.61) | GSK3BHAO1PLK1MMP2MMP9 | |
| SCHEMBL20097994 | 0.79 | HPGD (0.70) | GSK3BALDH1A1HIF1ATRPA1MAPK1 | |
| SCHEMBL7196791 | 0.78 | L3MBTL1 (0.55) | HAO1PLK1MMP2MMP9MMP8 | |
| SCHEMBL4842868 | 0.78 | HAO1 (0.67) | HAO1ALDH1A1MAPK1PLK1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994063-A | Novel method for synthesizing eremophilne intermediate | 上海博悦生物科技有限公司 | 2024-11-22 | — | — | CN | disclosed |
| US-7030153-B2 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | G.D. SEARLE & CO. (US) | 2006-04-18 | — | — | US | disclosed |
| US-7012094-B1 | Substituted furans and furanones for the treatment of inflammation | G.D. SEARLE, LLC (US) | 2006-03-14 | — | — | US | disclosed |
| US-6936632-B2 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2004-06-24 | — | — | US | disclosed |
| EP-1246825-B1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-20030153602-A1 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | G.D. SEARLE & CO. (US) | 2003-08-14 | — | — | US | disclosed |
| US-6599934-B1 | Effective and safe compounds having antiinflammatory and/or analgesic activity without erosion of the stomach | G.D. SEARLE & CO. | 2003-07-29 | — | — | US | disclosed |
| US-20030013744-A1 | 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents | G.D. SEARLE & CO. (US) | 2003-01-16 | — | — | US | disclosed |
| US-6492413-B2 | FOR USE IN THERAPY OF PAIN, ARTHRITIS, FEVER | G.D. SEARLE & CO. | 2002-12-10 | — | — | US | disclosed |
| US-6013839-A | REACTING A 2,4-DIHALOACETOPHENONE WITH A THIOLATING AGENT UNDER ANHYDROUS CONDITIONS; EFFICIENCY; INTERMEDIATES OF HERBICIDES E.G., BENZAMIDE DERIVATIVES | RHONE-POULENC AGRICULTURE LIMITED (GB) | 2000-01-11 | — | — | US | disclosed |
| EP-0883605-A1 | PROCESS FOR PREPARING 2-(THIOSUBSTITUTED)-4-HALOACETOPHENONES | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-12-16 | — | — | EP | disclosed |
| US-5786515-A | Synthesis of α-chloro or fluoro ketones | MERCK & CO., INC. (US) | 1998-07-28 | — | — | US | disclosed |
| EP-0851850-A1 | SYNTHESIS OF $g(a)-CHLORO OR FLUORO KETONES | Merck & Co., Inc. (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0679157-B1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | SEARLE & CO (US) | 1997-11-19 | — | — | EP | disclosed |
| WO-1997030026-A1 | PROCESS FOR PREPARING 2-(THIOSUBSTITUTED)-4-HALOACETOPHENONES | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |
| WO-1997010195-A1 | SYNTHESIS OF α-CHLORO OR FLUORO KETONES | MERCK & CO., INC. (US) | 1997-03-20 | — | — | WO | disclosed |
| WO-1994026731-A1 | 2-SUBSTITUTED-3,4-DIARYLTHIOPHENE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | MERCK FROSST CANADA INC. (CA) | 1994-11-24 | — | — | WO | disclosed |
| US-4631280-A | Pyridazine derivatives having a psychotropic action, and medicaments in which they are present | SANOFI (FR) | 1986-12-23 | — | — | US | disclosed |
| US-4565814-A | Pyridazine derivatives having a psychotropic action and compositions | SANOFI (FR) | 1986-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013744-A1 | 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents | NR3C1, FPR1, IL1B | GSK3B 3362/4885HAO1 341/4885ALDH1A1 261/4885 |
| US-20030153602-A1 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | NR3C1, FPR1, NR3C2 | GSK3B 3855/4885HAO1 363/4885ALDH1A1 274/4885 |
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | PTGS1, PTGS2, PTGER1 | GSK3B 4038/4885HAO1 605/4885ALDH1A1 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.