Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462970 | 0.89 | KCNH2 (0.43) | KCNH2KCNJ1MC4RCA12CA1 | |
| SCHEMBL7360603 | 0.87 | KCNH2 (0.45) | KCNH2KCNJ1MC4RFFAR1CA12 | |
| SCHEMBL7462980 | 0.86 | KCNH2 (0.44) | KCNH2KCNJ1FFAR1CA12CA1 | |
| SCHEMBL7363865 | 0.80 | KCNH2 (0.47) | KCNH2KCNJ1FFAR1CA12CA1 | |
| SCHEMBL8345485 | 0.80 | KCNH2 (0.47) | KCNH2KCNJ1MC4RFFAR1CA12 | |
| SCHEMBL7362630 | 0.79 | KCNH2 (0.47) | KCNH2KCNJ1FFAR1CA12CA1 | |
| SCHEMBL7363729 | 0.79 | KCNH2 (0.50) | KCNH2KCNJ1FFAR1CA12CA1 | |
| SCHEMBL7365988 | 0.75 | KCNH2 (0.45) | KCNH2KCNJ1FFAR1ANPEPERAP2 | |
| SCHEMBL8350250 | 0.74 | KCNH2 (0.46) | KCNH2KCNJ1FFAR1CA12CA1 | |
| SCHEMBL8343504 | 0.74 | KCNH2 (0.44) | KCNH2KCNJ1MC4RFFAR1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-B1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |