Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360603 | 0.93 | KCNH2 (0.45) | KCNH2KCNJ1FFAR1KCNN4KCNA5 | |
| SCHEMBL7359457 | 0.88 | FFAR1 (0.45) | FFAR1KCNN4KCNA5MMP12MMP13 | |
| SCHEMBL7361444 | 0.87 | KCNN4 (0.46) | FFAR1KCNN4KCNA5MMP12MMP13 | |
| SCHEMBL7464056 | 0.85 | FFAR1 (0.43) | FFAR1KCNN4KCNA5MMP12MMP13 | |
| SCHEMBL7365992 | 0.79 | KCNH2 (0.46) | KCNH2KCNJ1FFAR1CA12CA1 | |
| SCHEMBL7462980 | 0.79 | KCNH2 (0.44) | KCNH2KCNJ1FFAR1KCNN4KCNA5 | |
| SCHEMBL7368444 | 0.79 | FFAR1 (0.41) | FFAR1KCNN4KCNA5MMP12MMP13 | |
| SCHEMBL7362625 | 0.75 | KCNH2 (0.46) | KCNH2KCNJ1CA12CA1CA2 | |
| SCHEMBL7462970 | 0.74 | KCNH2 (0.43) | KCNH2KCNJ1CA12CA1CA2 | |
| SCHEMBL7458452 | 0.71 | KCNH2 (0.44) | KCNH2KCNJ1CDC25C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892780-B1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-0892780-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030971-A1 | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |