Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | CTSG | P08311 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358727 | 0.83 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7360978 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8602420 | 0.75 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7362713 | 0.71 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL14953599 | 0.70 | PDE4D (0.56) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7358967 | 0.70 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8599875 | 0.69 | POLB (0.65) | ALDH1A1ALDH3A1TSHRTP53HSD11B1 | |
| SCHEMBL8602385 | 0.69 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7359664 | 0.68 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7392643 | 0.68 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |
| WO-1996036611-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |