Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.63 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31051613 | 0.84 | CA12 (0.46) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL30375363 | 0.79 | CA12 (0.50) | KDM4EALDH1A1TDP1HTR6LMNA | |
| SCHEMBL7359664 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHCRTR1 | |
| SCHEMBL7360978 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHCRTR1 | |
| SCHEMBL7392643 | 0.72 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DHCRTR1 | |
| SCHEMBL11318137 | 0.71 | KMT2A (0.52) | MAPTKDM4EALDH1A1USP2MAPK1 | |
| SCHEMBL7358727 | 0.71 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL13633829 | 0.70 | GAA (0.63) | MAPTALDH1A1USP2LMNATSHR | |
| SCHEMBL7366201 | 0.69 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7362713 | 0.68 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728712-A | 3,4-disubstituted-phenylsulphonamides and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |