Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.53 |
| ▸ | PDE4A | P27815 | 8/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366340 | 0.85 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL5351550 | 0.84 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5351545 | 0.84 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7938329 | 0.82 | GAA (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5363118 | 0.80 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL5363123 | 0.80 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL7416129 | 0.80 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7416126 | 0.80 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7444218 | 0.79 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8069537 | 0.78 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | disclosed |