Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | GHSR | Q92847 | 7/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL8202168 | 1.00 | MEN1 (0.53) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL7366376 | 0.93 | MEN1 (0.46) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL7366382 | 0.93 | MEN1 (0.46) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL6839093 | 0.91 | KMT2A (0.64) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL23924434 | 0.91 | KMT2A (0.64) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL1901826 | 0.91 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL27650845 | 0.90 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL7122054 | 0.90 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL7122058 | 0.90 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL28940888 | 0.89 | MEN1 (0.43) | MEN1KMT2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804559-A4 | ENZYME FOR CLEAVAGE OF THE ANCHOR REGION OF SURFACE PROTEINS FROM GRAM POSITIVE BACTERIA | UNIV ROCKEFELLER (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-0804559-A1 | ENZYME FOR CLEAVAGE OF THE ANCHOR REGION OF SURFACE PROTEINS FROM GRAM POSITIVE BACTERIA | ROCKEFELLER UNIVERSITY (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011263-A1 | ENZYME FOR CLEAVAGE OF THE ANCHOR REGION OF SURFACE PROTEINS FROM GRAM POSITIVE BACTERIA | ROCKEFELLER UNIVERSITY (US) | 1996-04-18 | — | — | WO | disclosed |