Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.40 |
| ▸ | CFTR | P13569 | 7/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378017 | 0.83 | PDE4D (0.54) | PDE4DCFTR | |
| SCHEMBL26848367 | 0.76 | FYN (0.52) | CFTRAAK1 | |
| SCHEMBL11582196 | 0.69 | HSP90AA1 (0.43) | PDE4D | |
| SCHEMBL31579186 | 0.69 | TUBB4A (0.49) | AAK1 | |
| SCHEMBL7361447 | 0.65 | KMT2A (0.40) | PDE4D | |
| SCHEMBL21575262 | 0.64 | AAK1 (0.49) | CFTRAAK1 | |
| SCHEMBL7364772 | 0.63 | PDE4D (0.55) | PDE4D | |
| SCHEMBL13117256 | 0.62 | PDE10A (0.50) | — | |
| SCHEMBL5946490 | 0.62 | EGLN2 (0.45) | — | |
| SCHEMBL7294110 | 0.62 | PDE4A (0.60) | PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294730-A | A-Amino-4-alkoxy-3-polycycloalkyloxybenzyl cyanide derivatives | PFIZER INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5196426-A | CALCIUM INDEPENDENT C AMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5128358-A | Aryl substituted nitrogen heterocyclic antidepressants | PFIZER INC. (US) | 1992-07-07 | — | — | US | disclosed |
| WO-1987006576-A1 | CALCIUM INDEPENDENT CAMP PHOSPHODIESTERASE INHIBITOR ANTIDEPRESSANT | PFIZER INC. (US) | 1987-11-05 | — | — | WO | disclosed |