Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.54 |
| ▸ | PDE4A | P27815 | 6/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.54 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366534 | 0.83 | PDE4D (0.40) | PDE4DCFTR | |
| SCHEMBL7364772 | 0.81 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL26848367 | 0.80 | FYN (0.52) | CFTR | |
| SCHEMBL7368338 | 0.72 | PDE4B (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7396818 | 0.72 | PDE4B (0.62) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7359192 | 0.71 | PDE4B (0.64) | PDE4DPDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7363927 | 0.71 | PDE4B (0.58) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL31579186 | 0.70 | TUBB4A (0.49) | — | |
| SCHEMBL7360400 | 0.69 | PDE4B (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7359776 | 0.69 | PDE4B (0.59) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247725-B1 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0247725-A2 | Calcium independent camp phosphodiestrerase inhibitor antidepressant | PFIZER INC. (US) | 1987-12-02 | — | — | EP | disclosed |