Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375948 | 0.87 | KDM4E (0.57) | SMN1; SMN2P2RY1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL7370199 | 0.86 | TDP1 (0.52) | TDP1L3MBTL1F10ALDH1A1NPC1 | |
| SCHEMBL7698904 | 0.84 | TDP1 (0.46) | TDP1L3MBTL1F10ALDH1A1NPC1 | |
| SCHEMBL7372993 | 0.84 | TDP1 (0.52) | TDP1ALDH1A1P2RY1KMT2APOLB | |
| SCHEMBL3454297 | 0.83 | CYP1A2 (0.62) | TDP1L3MBTL1F10ALDH1A1NPC1 | |
| SCHEMBL5518570 | 0.83 | RAB9A (0.56) | TDP1F10ALDH1A1RAB9AP2RY1 | |
| SCHEMBL20831533 | 0.82 | TDP1 (0.72) | TDP1L3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL7367524 | 0.82 | ALDH1A1 (0.59) | TDP1MAPTL3MBTL1F10ALDH1A1 | |
| SCHEMBL7366824 | 0.81 | TDP1 (0.50) | TDP1MAPTL3MBTL1F10ALDH1A1 | |
| SCHEMBL7373604 | 0.81 | TDP1 (0.50) | TDP1MAPTL3MBTL1F10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |