Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.62 |
| ▸ | PDE4A | P27815 | 14/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358558 | 0.82 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7360400 | 0.80 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8632255 | 0.80 | PDE4A (0.71) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8631909 | 0.79 | PDE4A (0.70) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8479743 | 0.79 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7359192 | 0.78 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| Hydrochloric Acid SCHEMBL7363927 | 0.77 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7368236 | 0.75 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7368338 | 0.75 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7357311 | 0.74 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563143-A | ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISORDERS | PFIZER INC. (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0706795-A2 | Catechol diether compounds as inhibitors of TNF release | PFIZER INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |