Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.56 |
| ▸ | PDE4A | P27815 | 8/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374459 | 0.82 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL7358558 | 0.78 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL6040790 | 0.78 | MAPT (0.75) | MAPTGAARECQLGFERPKM | |
| SCHEMBL7359192 | 0.76 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7369053 | 0.76 | ALDH1A1 (0.65) | PDE4BPDE4APDE4CPDE4DMAPT | |
| Hydrochloric Acid SCHEMBL7363927 | 0.76 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7368338 | 0.76 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7366624 | 0.75 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7360400 | 0.74 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7368326 | 0.72 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |