Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7363276 | 0.99 | PLAU (0.55) | PLAUPLGS1PR1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7370990 | 0.98 | PLAU (0.55) | PLAUPLGS1PR1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7366875 | 0.88 | PLAU (0.42) | PLAUPLG | |
| SCHEMBL7369748 | 0.88 | PLG (0.44) | PLAUPLGS1PR1HTR2AHTR2C | |
| SCHEMBL7053013 | 0.88 | PLG (0.43) | PLAUPLGS1PR1HTR2AHTR2C | |
| SCHEMBL6437765 | 0.81 | PLAU (0.56) | PLAUPLGS1PR1HTR2AHTR2C | |
| SCHEMBL7377720 | 0.81 | PLAU (0.46) | PLAUPLG | |
| Hydrochloric Acid SCHEMBL6438808 | 0.80 | PLAU (0.55) | PLAUPLGS1PR1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7370464 | 0.80 | PLAU (0.45) | PLAUPLG | |
| Hydrochloric Acid SCHEMBL7379597 | 0.80 | PLAU (0.47) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |