Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 2/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053013 | 0.99 | PLG (0.43) | PLGPLAUCNR2S1PR1HTT | |
| SCHEMBL7375649 | 0.91 | NR1D1 (0.35) | PLGPLAUALDH1A1 | |
| SCHEMBL7366690 | 0.88 | PLAU (0.56) | PLGPLAUS1PR1HTTNPSR1 | |
| Hydrochloric Acid SCHEMBL7363276 | 0.87 | PLAU (0.55) | PLGPLAUS1PR1HTTNPSR1 | |
| Hydrochloric Acid SCHEMBL7370990 | 0.87 | PLAU (0.55) | PLGPLAUS1PR1HTTNPSR1 | |
| SCHEMBL7050066 | 0.85 | PLAU (0.39) | PLAUHTTNPSR1MAPK1ALDH1A1 | |
| SCHEMBL7049646 | 0.85 | PLAU (0.43) | PLAUALDH1A1THRB | |
| SCHEMBL7377977 | 0.85 | PLAU (0.36) | PLAUHTTNPSR1ALDH1A1PTGER2 | |
| SCHEMBL7369744 | 0.83 | PLG (0.43) | PLGPLAUCNR2S1PR1MAPK1 | |
| SCHEMBL6436326 | 0.83 | SMN1; SMN2 (0.37) | PLAUHTTNPSR1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |