Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL850967 | 0.86 | ELANE (0.53) | TDP1ALDH1A1GAA | |
| SCHEMBL851191 | 0.85 | TDP1 (0.52) | TDP1ALDH1A1RAB9AGAAROCK2 | |
| SCHEMBL20818012 | 0.83 | TDP1 (1.00) | TDP1ALDH1A1RAB9AGAAMAPK8 | |
| SCHEMBL7373227 | 0.82 | TDP1 (0.76) | TDP1ALDH1A1RAB9AGAAHPGD | |
| SCHEMBL620646 | 0.82 | TDP1 (0.76) | TDP1ALDH1A1RAB9ADRD1GAA | |
| SCHEMBL28069342 | 0.82 | TDP1 (0.76) | TDP1ALDH1A1RAB9ADRD1GAA | |
| SCHEMBL28734386 | 0.80 | TDP1 (0.72) | TDP1ALDH1A1RAB9ADRD1CYP1A2 | |
| SCHEMBL5749934 | 0.80 | TDP1 (0.72) | TDP1ALDH1A1RAB9ADRD1GAA | |
| SCHEMBL620688 | 0.78 | TDP1 (0.69) | TDP1ALDH1A1RAB9ADRD1GAA | |
| SCHEMBL10976046 | 0.76 | TDP1 (0.67) | TDP1ALDH1A1RAB9ADRD1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |