Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362007 | 0.85 | HCRTR1 (0.49) | TDP1ALDH1A1GAAMAPK8HCRTR1 | |
| SCHEMBL7366718 | 0.85 | TDP1 (0.71) | TDP1ALDH1A1RAB9AGAAMAPK8 | |
| SCHEMBL861902 | 0.83 | TDP1 (0.71) | TDP1ALDH1A1RAB9APDE10AGAA | |
| SCHEMBL11810048 | 0.82 | PDE10A (0.60) | TDP1ALDH1A1RAB9APDE10AGAA | |
| SCHEMBL850967 | 0.82 | ELANE (0.53) | TDP1ALDH1A1GAAHCRTR1HCRTR2 | |
| SCHEMBL2779334 | 0.81 | RAB9A (0.76) | TDP1ALDH1A1RAB9APDE10AGAA | |
| SCHEMBL2779361 | 0.81 | KMT2A (0.65) | TDP1ALDH1A1RAB9APDE10AGAA | |
| SCHEMBL1797073 | 0.81 | TDP1 (0.56) | TDP1ALDH1A1RAB9APDE10AGAA | |
| SCHEMBL6457226 | 0.81 | TDP1 (0.64) | TDP1ALDH1A1RAB9APDE10AGAA | |
| SCHEMBL2781160 | 0.81 | GAA (0.67) | TDP1ALDH1A1RAB9APDE10AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |
| US-4085111-A | ANTIALLERGENS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) | 1978-04-18 | — | — | US | disclosed |