Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.59 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751498 | 0.84 | MAP3K14 (0.59) | MAP3K14HTR1ACYP2D6SLC6A4LTB4R | |
| SCHEMBL19646975 | 0.80 | MAP3K14 (0.55) | MAP3K14HTR1ACYP2D6SLC6A4LTB4R | |
| SCHEMBL16137573 | 0.78 | MAP3K14 (0.65) | MAP3K14HTR1ACYP2D6SLC6A4 | |
| SCHEMBL14064253 | 0.77 | BDKRB1 (0.44) | MAP3K14BDKRB1CD274HTR1ASLC6A4 | |
| SCHEMBL1111009 | 0.76 | MAP3K14 (0.67) | MAP3K14 | |
| SCHEMBL14183091 | 0.76 | MAP3K14 (0.67) | MAP3K14 | |
| SCHEMBL13614279 | 0.76 | MAP3K14 (0.50) | MAP3K14HTR1ACYP2D6SLC6A4HRH3 | |
| SCHEMBL12501454 | 0.75 | MAP3K14 (0.65) | MAP3K14HTR1ACYP2D6SLC6A4 | |
| SCHEMBL3556913 | 0.75 | MAP3K14 (0.65) | MAP3K14HTR1A | |
| SCHEMBL22143947 | 0.75 | MAP3K14 (0.65) | MAP3K14HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |