Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 5/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585192 | 0.81 | BDKRB1 (0.49) | BDKRB1 | |
| SCHEMBL3585187 | 0.81 | BDKRB1 (0.49) | BDKRB1 | |
| SCHEMBL14518509 | 0.80 | KDM4E (0.41) | PDPK1MAP3K14 | |
| SCHEMBL3593320 | 0.79 | BDKRB1 (0.49) | BDKRB1 | |
| SCHEMBL3593313 | 0.79 | BDKRB1 (0.49) | BDKRB1 | |
| SCHEMBL28449906 | 0.77 | ADRA2A (0.47) | PDPK1MAP3K14 | |
| SCHEMBL7366724 | 0.77 | MAP3K14 (0.59) | BDKRB1CD274HTR1AMAP3K14NCF1 | |
| SCHEMBL29920817 | 0.77 | ADRA2A (0.47) | HTR1APDPK1MAP3K14TRPV1 | |
| SCHEMBL22997177 | 0.74 | PDPK1 (0.52) | PDPK1 | |
| SCHEMBL130896 | 0.74 | PDPK1 (0.52) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425631-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-09-16 | — | — | US | disclosed |