Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 16/20 | 0.75 |
| ▸ | F2 | P00734 | 15/20 | 0.75 |
| ▸ | PRSS1 | P07477 | 14/20 | 0.75 |
| ▸ | F9 | P00740 | 3/20 | 0.75 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | ICMT | O60725 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367326 | 0.86 | F10 (1.00) | F10F2PRSS1F9PRSS2 | |
| SCHEMBL31127597 | 0.83 | CNR2 (0.54) | F10F2PRSS1F9CNR2 | |
| SCHEMBL7371135 | 0.81 | F2 (0.59) | F10F2PRSS1F9HRH3 | |
| SCHEMBL7449310 | 0.81 | F10 (1.00) | F10F2PRSS1F9PRSS2 | |
| SCHEMBL6616732 | 0.75 | F10 (0.78) | F10F2PRSS1F9PRSS2 | |
| SCHEMBL1982997 | 0.75 | F10 (1.00) | F10F2PRSS1F9PRSS2 | |
| SCHEMBL18229449 | 0.75 | LMNA (0.57) | HRH3 | |
| SCHEMBL31127596 | 0.74 | F2 (0.49) | F10F2PRSS1F9CNR2 | |
| SCHEMBL2008370 | 0.74 | ICMT (0.81) | CNR2ICMT | |
| SCHEMBL31127587 | 0.74 | ANO1 (0.52) | F10F2PRSS1F9CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | claimed |
| US-6043257-A | ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5886191-A | ANTICOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-03-23 | — | — | US | disclosed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | disclosed |