Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367688 | 0.87 | KDM4E (0.54) | KDM4ETDP1NAPRTHTTALDH1A1 | |
| SCHEMBL7369692 | 0.84 | KDM4E (0.50) | KDM4ETDP1NAPRTSLC40A1HTT | |
| SCHEMBL7367740 | 0.83 | KDM4E (0.47) | KDM4ETDP1SLC40A1HTTALDH1A1 | |
| SCHEMBL7361928 | 0.81 | KDM4E (0.55) | KDM4ETDP1NAPRTHTTALDH1A1 | |
| SCHEMBL9378111 | 0.80 | KDM4E (0.48) | KDM4ETDP1NAPRTKCNA5ALDH1A1 | |
| SCHEMBL7366150 | 0.78 | KDM4E (0.49) | KDM4ETDP1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL15655701 | 0.76 | MEN1 (0.50) | KDM4ETDP1CYP11B1CYP11B2KCNA5 | |
| SCHEMBL12939848 | 0.70 | PKM (0.46) | CYP11B1CYP11B2ALDH1A1KCNH2SMN1; SMN2 | |
| SCHEMBL7365920 | 0.69 | KDM4E (0.57) | KDM4ETDP1NAPRTALDH1A1GAA | |
| SCHEMBL7454925 | 0.69 | MEN1 (0.64) | KDM4ETDP1HTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |