Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366991 | 1.00 | CARM1 (0.46) | CARM1PRMT6PDE4APDE4BPDE4C | |
| SCHEMBL7368199 | 0.90 | SLC22A12 (0.41) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL7369357 | 0.90 | KMT2A (0.50) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL7371277 | 0.87 | ALDH1A1 (0.48) | GAA | |
| SCHEMBL7406794 | 0.86 | MAPK8 (0.51) | — | |
| SCHEMBL7681556 | 0.85 | CARM1 (0.48) | CARM1PRMT6 | |
| SCHEMBL7681563 | 0.85 | CARM1 (0.48) | CARM1PRMT6 | |
| SCHEMBL7371639 | 0.85 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL4825943 | 0.85 | AURKA (0.43) | GAA | |
| SCHEMBL7404893 | 0.85 | MAPK8 (0.45) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |