Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | UGCG | Q16739 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681556 | 1.00 | CARM1 (0.48) | CARM1MAPK8PRMT6UGCGPOLB | |
| SCHEMBL7369357 | 0.88 | KMT2A (0.50) | MAPK8 | |
| SCHEMBL7366991 | 0.85 | CARM1 (0.46) | CARM1PRMT6 | |
| SCHEMBL7366994 | 0.85 | CARM1 (0.46) | CARM1PRMT6 | |
| SCHEMBL7405222 | 0.85 | MAPK8 (0.47) | CARM1MAPK8PRMT6UGCGPOLB | |
| SCHEMBL7405218 | 0.85 | MAPK8 (0.47) | CARM1MAPK8PRMT6UGCGPOLB | |
| SCHEMBL7368199 | 0.81 | SLC22A12 (0.41) | — | |
| SCHEMBL7406794 | 0.80 | MAPK8 (0.51) | MAPK8POLB | |
| SCHEMBL7371277 | 0.80 | ALDH1A1 (0.48) | MAPK8POLB | |
| SCHEMBL7370609 | 0.79 | MEN1 (0.44) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |