Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 4/20 | 0.53 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365684 | 1.00 | TPH1 (0.53) | TPH1GRIA1GRIA3SLC7A5PKM | |
| SCHEMBL7159035 | 0.88 | SLC7A5 (0.46) | GRIA1GRIA3SLC7A5PKMGRIA2 | |
| SCHEMBL8129370 | 0.88 | SLC7A5 (0.46) | GRIA1GRIA3SLC7A5PKMGRIA2 | |
| SCHEMBL7159040 | 0.88 | SLC7A5 (0.46) | GRIA1GRIA3SLC7A5PKMGRIA2 | |
| SCHEMBL7406145 | 0.87 | TPH1 (0.46) | TPH1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL7406141 | 0.87 | TPH1 (0.46) | TPH1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8133915 | 0.86 | TRPV1 (0.46) | TPH1 | |
| SCHEMBL8133906 | 0.86 | TRPV1 (0.46) | TPH1 | |
| SCHEMBL7407074 | 0.85 | GRIA1 (0.42) | TPH1GRIA1GRIA3SLC7A5GRIA2 | |
| SCHEMBL7407067 | 0.85 | GRIA1 (0.42) | TPH1GRIA1GRIA3SLC7A5GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994107-A1 | 5-Arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds | H. LUNDBECK A/S (DK) | 2000-04-19 | — | — | EP | disclosed |
| EP-0726896-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012587-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |