Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GRM6 | O15303 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406141 | 1.00 | TPH1 (0.46) | TPH1MEN1KMT2AGRM6CYP1A2 | |
| SCHEMBL8128581 | 0.88 | KIF11 (0.39) | MEN1KMT2AGRM6CYP1A2CYP2C9 | |
| SCHEMBL8128585 | 0.88 | KIF11 (0.39) | MEN1KMT2AGRM6CYP1A2CYP2C9 | |
| SCHEMBL7367073 | 0.87 | TPH1 (0.53) | TPH1MEN1KMT2ACYP2C9ALOX15 | |
| SCHEMBL7365684 | 0.87 | TPH1 (0.53) | TPH1MEN1KMT2ACYP2C9ALOX15 | |
| SCHEMBL7452730 | 0.81 | SLC1A3 (0.35) | MEN1KMT2AGRM6CYP1A2CYP2C9 | |
| SCHEMBL7452720 | 0.81 | SLC1A3 (0.35) | MEN1KMT2AGRM6CYP1A2CYP2C9 | |
| SCHEMBL7408347 | 0.81 | SLC7A11 (0.45) | TPH1MEN1KMT2ACYP1A2KDM4E | |
| SCHEMBL7408342 | 0.81 | SLC7A11 (0.45) | TPH1MEN1KMT2ACYP1A2KDM4E | |
| SCHEMBL8125246 | 0.81 | NOS1 (0.43) | KMT2AKIF11GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056837-C | 5-arylisoxazol-4-yl-substituted 2-aminocarboxylic acid compounds | LUNDBECK & CO AS H (DK) | 2000-09-27 | — | — | CN | disclosed |
| EP-0994107-A1 | 5-Arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds | H. LUNDBECK A/S (DK) | 2000-04-19 | — | — | EP | disclosed |
| CN-1136810-A | 5-arylisoxazol-4-yl-substituted 2-aminocarboxylic acid compounds | LUNDBECK & CO AS H (DK) | 1996-11-27 | — | — | CN | disclosed |
| EP-0726896-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012587-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |