Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365091 | 0.86 | F2 (0.39) | F2APPNPSR1ALDH1A1KDM4E | |
| SCHEMBL7361749 | 0.80 | F2 (0.48) | F2 | |
| SCHEMBL7368343 | 0.73 | F2 (0.56) | F2F10 | |
| SCHEMBL7362729 | 0.71 | F2 (0.46) | F2 | |
| SCHEMBL7364614 | 0.69 | F2 (0.68) | F2 | |
| SCHEMBL7223343 | 0.67 | MAPT (0.45) | F2LMNAAPPPTGDR2ALDH1A1 | |
| SCHEMBL31070228 | 0.66 | ALDH1A1 (0.51) | LMNANPSR1ALDH1A1KDM4EGAA | |
| SCHEMBL5217903 | 0.66 | ALDH1A1 (0.51) | LMNANPSR1ALDH1A1KDM4EGAA | |
| SCHEMBL7015258 | 0.66 | F2 (0.44) | F2LMNAAPPALDH1A1KDM4E | |
| SCHEMBL7408234 | 0.65 | EGLN1 (0.39) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |