Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 14/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365091 | 0.75 | F2 (0.39) | F2 | |
| SCHEMBL7368453 | 0.74 | F2 (0.47) | F2PRSS1F10 | |
| SCHEMBL7367159 | 0.73 | F2 (0.40) | F2F10 | |
| SCHEMBL7369356 | 0.72 | F2 (1.00) | F2PRSS1 | |
| SCHEMBL7365971 | 0.65 | F2 (0.54) | F2PRSS1F10 | |
| SCHEMBL10987788 | 0.65 | F2 (0.43) | F2MEN1KMT2A | |
| SCHEMBL7370558 | 0.65 | F2 (0.43) | F2F10 | |
| SCHEMBL10996688 | 0.64 | F2 (0.38) | F2PTGER1MEN1KMT2A | |
| SCHEMBL7362729 | 0.64 | F2 (0.46) | F2PRSS1 | |
| SCHEMBL7361749 | 0.63 | F2 (0.48) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259506-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001038323-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2001-05-31 | — | — | WO | disclosed |