Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.64 |
| ▸ | MMP2 | P08253 | 13/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 13/20 | 0.62 |
| ▸ | MMP8 | P22894 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6379949 | 0.99 | MMP9 (0.63) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| SCHEMBL5097962 | 0.91 | ADAMTS4 (0.77) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| SCHEMBL11956306 | 0.91 | ADAMTS4 (0.77) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| SCHEMBL10118180 | 0.90 | MMP9 (0.65) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| SCHEMBL7372375 | 0.90 | MMP9 (0.66) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| Hydrochloric Acid SCHEMBL7347875 | 0.90 | ADAMTS4 (0.76) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| Hydrochloric Acid SCHEMBL5213017 | 0.90 | ADAMTS4 (0.76) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| Hydrochloric Acid SCHEMBL7343718 | 0.89 | MMP9 (0.66) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| Hydrochloric Acid SCHEMBL7343724 | 0.89 | MMP9 (0.66) | MMP9MMP2ADAMTS4MMP13MMP8 | |
| SCHEMBL13253256 | 0.88 | MMP9 (0.80) | MMP9MMP2ADAMTS4MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028716-A1 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1998025597-A2 | METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION | WARNER-LAMBERT COMPANY (US) | 1998-06-18 | — | — | WO | disclosed |