Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286337 | 0.87 | HTT (0.50) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1399017 | 0.87 | HTT (0.50) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1399018 | 0.87 | HTT (0.50) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL16281851 | 0.84 | SYK (0.49) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL328631 | 0.84 | SYK (0.49) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8981259 | 0.84 | MEN1 (0.55) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL22829843 | 0.81 | HTT (0.47) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL26192488 | 0.80 | SYK (0.46) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7374261 | 0.80 | SYK (0.43) | SYKMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1479625 | 0.79 | CTSS (0.49) | MEN1KMT2ACTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224186-A2 | PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION | COR THERAPEUTICS, INC. (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030780-A2 | PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION | COR THERAPEUTICS, INC. (US) | 2001-05-03 | — | — | WO | disclosed |