Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 8/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | C5 | P01031 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28427762 | 0.96 | TDP1 (0.80) | TDP1SMN1; SMN2HPGDRECQLFAAH | |
| Ethopabate SCHEMBL540932 | 0.85 | TDP1 (1.00) | TDP1SMN1; SMN2HPGDCDK1MEN1 | |
| Ethopabate SCHEMBL29625103 | 0.85 | TDP1 (1.00) | TDP1SMN1; SMN2HPGDCDK1MEN1 | |
| SCHEMBL13637511 | 0.85 | TDP1 (0.62) | TDP1SMN1; SMN2HPGDRECQLFAAH | |
| SCHEMBL28489272 | 0.84 | TDP1 (0.60) | TDP1SMN1; SMN2HPGDRECQLFAAH | |
| Ethopabate SCHEMBL28629644 | 0.84 | TDP1 (0.97) | TDP1SMN1; SMN2HPGDCDK1MEN1 | |
| SCHEMBL19549621 | 0.82 | MAOA (0.60) | MAOAMAOBMEN1KMT2AALDH1A1 | |
| SCHEMBL26355067 | 0.82 | MAOA (0.60) | MAOAMAOBMEN1KMT2AALDH1A1 | |
| SCHEMBL28715731 | 0.80 | MAOA (0.53) | HPGDMAOAMAOBMEN1MAPT | |
| SCHEMBL3738882 | 0.80 | MAOA (0.49) | TDP1HPGDMAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |