Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713657 | 0.91 | ALDH1A1 (0.48) | ALDH1A1CYP1A1CYP1B1AHR | |
| SCHEMBL8444519 | 0.87 | ADORA2A (0.49) | ADORA2AADORA1EPAS1 | |
| SCHEMBL3386175 | 0.84 | ALDH1A1 (0.41) | ALDH1A1FFAR4CYP1A1CYP1B1SLC22A12 | |
| SCHEMBL509273 | 0.84 | ALDH1A1 (0.41) | ALDH1A1FFAR4CYP1A1CYP1B1EPAS1 | |
| SCHEMBL309328 | 0.81 | ALDH1A1 (0.38) | ALDH1A1CYP1A1CYP1B1TP53 | |
| SCHEMBL926505 | 0.80 | CA2 (0.41) | ADORA2AADORA1 | |
| SCHEMBL2083820 | 0.79 | ALDH1A1 (0.44) | ALDH1A1FFAR4CYP1A1CYP1B1NFE2L2 | |
| SCHEMBL4730537 | 0.79 | CYP1A1 (0.47) | ALDH1A1CYP1A1CYP1B1NFE2L2AHR | |
| SCHEMBL4174925 | 0.79 | EPAS1 (0.39) | ALDH1A1EPAS1 | |
| SCHEMBL2848532 | 0.79 | ADORA2A (0.50) | ADORA2AADORA1ALDH1A1EPAS1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |