Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 10/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750048 | 1.00 | CTSK (0.44) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL10669320 | 1.00 | CTSK (0.44) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL10424653 | 0.93 | CTSS (0.43) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL9750429 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL7273551 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL10425107 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL7307731 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL7307733 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL9533345 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 | |
| SCHEMBL7307737 | 0.88 | CTSS (0.41) | CTSKCTSSRENAAK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| WO-1988003022-A1 | RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |