Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371463 | 0.84 | GRM5 (0.42) | GRM5TRPV1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL7364719 | 0.79 | GRM5 (0.43) | GRM5TRPV1RAB9AALDH1A1MAPT | |
| SCHEMBL28484824 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EL3MBTL1CYP1A2 | |
| SCHEMBL28484823 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EL3MBTL1CYP1A2 | |
| SCHEMBL26725953 | 0.71 | MAPT (0.40) | RAB9AALDH1A1MAPTPOLBGAA | |
| SCHEMBL19100954 | 0.71 | MAPT (0.38) | RAB9AALDH1A1MAPTPOLBGAA | |
| SCHEMBL19100955 | 0.71 | MAPT (0.38) | RAB9AALDH1A1MAPTPOLBGAA | |
| SCHEMBL4563772 | 0.69 | CYP1A2 (0.69) | GRM5ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL10329160 | 0.69 | MAPT (0.51) | RAB9ANPC1ALDH1A1MAPTPOLB | |
| SCHEMBL30628910 | 0.69 | MAPT (0.51) | RAB9ANPC1ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971928-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042712-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |