Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371463 | 0.82 | GRM5 (0.42) | GRM5ALDH1A1TRPV1LMNAMAPT | |
| SCHEMBL6276159 | 0.80 | ADRB1 (0.48) | MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7367453 | 0.79 | GRM5 (0.38) | GRM5ALDH1A1POLBTRPV1MAPT | |
| SCHEMBL28744241 | 0.77 | ALDH1A1 (0.51) | ALDH1A1POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL14377204 | 0.76 | MEN1 (0.43) | ALDH1A1POLBRPS6KB1LMNAMAPT | |
| SCHEMBL4563772 | 0.76 | CYP1A2 (0.69) | GRM5ALDH1A1POLBLMNAMAPT | |
| SCHEMBL20339483 | 0.75 | TRPV1 (0.61) | ALDH1A1TRPV1HSD11B1 | |
| SCHEMBL4606448 | 0.74 | ALDH1A1 (0.49) | ALDH1A1TRPV1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL18282577 | 0.73 | ALDH1A1 (0.41) | ALDH1A1POLBMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL782123 | 0.72 | MAPT (0.44) | GRM5ALDH1A1RPS6KB1TRPV1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971928-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042712-A1 | QUINOLINE-2(1H)-ONE AND DIHYDROQUINOLINE-2(1H)-ONE DERIVATIVES AS LIGANDS OF 5-HT, 5-HT2 AND 5-HT1-LIKE RECEPTORS | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |