Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.43 |
| ▸ | F2 | P00734 | 7/20 | 0.43 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6434346 | 0.94 | F2 (0.40) | PLAUF2PRSS12F10SMN1; SMN2 | |
| SCHEMBL6433874 | 0.87 | F2 (0.37) | PLAUF2PRSS12F10SMN1; SMN2 | |
| SCHEMBL7365772 | 0.85 | PRSS12 (0.37) | PLAUF2PRSS12F10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6432998 | 0.83 | PLAU (0.44) | PLAU | |
| SCHEMBL7403972 | 0.83 | PLAU (0.44) | PLAUF2PRSS12SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7447057 | 0.76 | CA1 (0.46) | PLAUF2 | |
| SCHEMBL6436503 | 0.75 | CA1 (0.48) | PLAUSMN1; SMN2 | |
| SCHEMBL7369537 | 0.74 | CTSA (0.46) | — | |
| Trifluoroacetic Acid SCHEMBL6437287 | 0.74 | PLAU (0.64) | PLAUSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6435316 | 0.73 | PLAU (0.56) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |