Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | ECE1 | P42892 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698107 | 0.95 | PDE4D (0.43) | KDM4EL3MBTL1GPR35PDE4APDE4B | |
| SCHEMBL4704138 | 0.93 | KDM4E (0.55) | KDM4EL3MBTL1GPR35ALOX15PDE4A | |
| SCHEMBL18552419 | 0.79 | KDM4E (0.44) | KDM4EL3MBTL1GPR35PDE4APDE4B | |
| SCHEMBL31525613 | 0.79 | PTGER4 (0.43) | KDM4EL3MBTL1MAPTCYP1A2GAA | |
| SCHEMBL31525491 | 0.78 | PDE4D (0.43) | KDM4EL3MBTL1GPR35PDE4APDE4B | |
| SCHEMBL6080899 | 0.76 | PTGER4 (0.44) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7107317 | 0.74 | CTSA (0.47) | KDM4EL3MBTL1MAPTCYP1A2GAA | |
| SCHEMBL6591002 | 0.73 | KDM4E (0.51) | KDM4EL3MBTL1GPR35ALOX15PDE4B | |
| SCHEMBL6593931 | 0.73 | PTGER1 (0.49) | KDM4EL3MBTL1MAPTCYP1A2RAB9A | |
| SCHEMBL31432467 | 0.72 | KDM4E (0.47) | KDM4EL3MBTL1ALOX15MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |