SCHEMBL7367608

SCHEMBL7367608

COC(=O)Cc1cc2cc(C#N)ccc2[nH]1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 2/20 0.44
PGR P06401 2/20 0.44
NR3C2 P08235 2/20 0.44
DRD2 P14416 6/20 0.44
DRD4 P21917 6/20 0.44
DRD3 P35462 6/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
CYP19A1 P11511 1/20 0.43
SIRT1 Q96EB6 1/20 0.42
MTNR1A P48039 2/20 0.41
MTNR1B P49286 1/20 0.41
IDH1 O75874 2/20 0.40
GSK3B P49841 1/20 0.39
CNR1 P21554 1/20 0.39
IMPDH2 P12268 1/20 0.39
IMPDH1 P20839 1/20 0.39
PIN1 Q13526 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3528754 0.87 MTNR1A (0.45) NR3C1PGRNR3C2DRD2DRD4
SCHEMBL853728 0.80 FLT3 (0.49) SMN1; SMN2SIRT1MTNR1AMTNR1B
SCHEMBL9679411 0.79 MTNR1A (0.64) MTNR1AMTNR1B
SCHEMBL31472119 0.79 FLT3 (0.50) SMN1; SMN2SIRT1MTNR1AMTNR1B
SCHEMBL1420627 0.77 ALOX15 (0.43) NR3C1PGRNR3C2DRD2DRD4
SCHEMBL8686875 0.77 MTNR1A (0.56) SMN1; SMN2MTNR1AMTNR1BGSK3B
SCHEMBL21822216 0.76 SMN1; SMN2 (0.47) NR3C1PGRNR3C2DRD2DRD4
SCHEMBL10066178 0.76 CYP19A1 (0.51) NR3C1PGRNR3C2DRD2DRD4
SCHEMBL1420556 0.76 CYP19A1 (0.51) NR3C1PGRNR3C2DRD2DRD4
SCHEMBL5777259 0.76 SMN1; SMN2 (0.40) SMN1; SMN2SIRT1MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043257-A ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-03-28 US disclosed
EP-0960102-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN Du Pont Pharmaceuticals Company (US) 1999-12-01 EP disclosed
US-5886191-A ANTICOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 1999-03-23 US disclosed
WO-1998001428-A1 AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN DU PONT PHARMACEUTICALS COMPANY (US) 1998-01-15 WO disclosed