Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 3/20 | 0.39 |
| ▸ | ADH1A | P07327 | 3/20 | 0.39 |
| ▸ | ADH7 | P40394 | 3/20 | 0.39 |
| ▸ | ADH1C | P00326 | 2/20 | 0.39 |
| ▸ | DGKA | P23743 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651631 | 0.79 | CYP1A2 (0.52) | ADH1BADH1AADH7ADH1CEPHX1 | |
| SCHEMBL9099964 | 0.78 | DGKA (0.56) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL23876838 | 0.78 | DGKA (0.43) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL7357567 | 0.77 | DGKA (0.40) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL1401010 | 0.76 | ADH1B (0.39) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL24013228 | 0.76 | ADH1B (0.36) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL8176277 | 0.75 | CYP1A2 (0.52) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL9235433 | 0.75 | ADH1B (0.37) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL7488988 | 0.75 | DGKA (0.62) | ADH1BADH1AADH7ADH1CDGKA | |
| SCHEMBL1401029 | 0.75 | ADH1B (0.37) | ADH1BADH1AADH7ADH1CDGKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173177-A1 | USE OF MACROLIDE COMPOUNDS FOR THE TREATMENT OF DRY EYE | Sucampo AG (CH) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066122-A1 | USE OF MACROLIDE COMPOUNDS FOR THE TREATMENT OF DRY EYE | SUCAMPO AG (CH) | 2000-11-09 | — | — | WO | disclosed |