Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22987088 | 0.90 | GAA (0.48) | S1PR3PTPN1MEN1LMNACYP3A4 | |
| SCHEMBL27264213 | 0.84 | CYP3A4 (0.49) | THRATHRBMEN1NR1I2LMNA | |
| SCHEMBL99475 | 0.84 | TSHR (0.53) | LMNACYP3A4ADRA2AHTR2BTSHR | |
| SCHEMBL668981 | 0.83 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL8679152 | 0.83 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL10539639 | 0.83 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL3906642 | 0.83 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL35210991 | 0.83 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL4462194 | 0.83 | PTPN11 (0.64) | PTPN11S1PR3PTPN1PTPN6PLA2G2A | |
| SCHEMBL7267139 | 0.83 | GAA (0.50) | LMNACYP3A4ADRA2AHTR2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243959-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-08-19 | — | — | EP | disclosed |
| US-4870074-A | Substituted benzamide derivatives, for enhancing gastrointestinal motility | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0243959-A1 | Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-04 | — | — | EP | disclosed |