Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367744 | 0.81 | PDE4B (0.45) | PDE4BTP53ADORA2AADORA2BADORA1 | |
| SCHEMBL4052027 | 0.72 | PDE4B (0.54) | PDE4BMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7314230 | 0.70 | PDE4B (0.52) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL7304940 | 0.69 | PDE4B (0.59) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL7315199 | 0.69 | PDE4B (0.49) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL4049841 | 0.67 | TBXAS1 (0.49) | PDE4BADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL7316189 | 0.67 | PDE4B (0.57) | PDE4BADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL7316210 | 0.66 | PDE4B (0.58) | PDE4BADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL4056450 | 0.66 | PDE4B (0.46) | PDE4BADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL7306528 | 0.66 | PDE4B (0.52) | PDE4BADORA2AADORA2BADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |