SCHEMBL7367762

SCHEMBL7367762

COC(=O)c1ncccc1C(=O)c1ccc(C(=O)O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.50
KDM4E B2RXH2 7/20 0.48
ALDH1A1 P00352 7/20 0.48
ALOX15 P16050 2/20 0.47
MAPT P10636 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
CYP3A4 P08684 1/20 0.47
TSHR P16473 1/20 0.47
BLM P54132 1/20 0.47
AGER Q15109 1/20 0.47
TDP1 Q9NUW8 2/20 0.47
DHODH Q02127 1/20 0.45
HTT P42858 3/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
KDM6B O15054 1/20 0.43
KDM5C P41229 1/20 0.43
KDM4C Q9H3R0 1/20 0.43
KDM2A Q9Y2K7 1/20 0.43
KDM3A Q9Y4C1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7368006 0.91 L3MBTL1 (0.53) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL2211216 0.91 L3MBTL1 (0.53) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL7360329 0.88 KDM4E (0.56) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL7368513 0.88 TDP1 (0.50) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL7360249 0.88 KDM4E (0.51) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL10480612 0.87 L3MBTL1 (0.49) L3MBTL1ALOX15MAPTTSHRTDP1
SCHEMBL7364122 0.87 KMT2A (0.52) L3MBTL1KDM4EALDH1A1MAPTNPSR1
SCHEMBL7370163 0.87 L3MBTL1 (0.49) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL7365837 0.85 L3MBTL1 (0.47) L3MBTL1KDM4EALDH1A1ALOX15MAPT
SCHEMBL7367595 0.84 KDM4E (0.67) L3MBTL1KDM4EALDH1A1ALOX15MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5716954-A ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES SYNTEX U.S.A. INC. (US) 1998-02-10 US disclosed
EP-0612321-A1 PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1994-08-31 EP disclosed
WO-1993007146-A1 BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY SYNTEX (U.S.A.) INC. (US) 1993-04-15 WO disclosed