Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | ACE | P12821 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.33 |
| ▸ | ITGAV | P06756 | 3/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28985130 | 1.00 | CRBN (0.37) | CRBNACEPOLBALDH1A1ITGB1 | |
| SCHEMBL27273677 | 1.00 | CRBN (0.37) | CRBNACEPOLBALDH1A1ITGB1 | |
| SCHEMBL10345832 | 0.74 | — | — | |
| SCHEMBL10345953 | 0.74 | — | — | |
| SCHEMBL7403414 | 0.73 | ITGB1 (0.33) | CRBNACEPOLBALDH1A1ITGB1 | |
| SCHEMBL21253514 | 0.72 | CRBN (0.41) | CRBNMAPK1MEN1KMT2A | |
| SCHEMBL7366180 | 0.71 | GPBAR1 (0.47) | MAPK1HPGD | |
| SCHEMBL27275908 | 0.71 | GPBAR1 (0.47) | MAPK1HPGD | |
| SCHEMBL288354 | 0.71 | P2RX7 (0.45) | ACE | |
| SCHEMBL14750046 | 0.71 | P2RX7 (0.45) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109369779-B | Synthetic method of taltirelin | 江苏诺泰澳赛诺生物制药股份有限公司 | 2021-12-10 | — | — | CN | claimed |
| CN-109369779-A | A kind of synthetic method of Taltirelin | 江苏诺泰澳赛诺生物制药股份有限公司 | 2019-02-22 | — | — | CN | claimed |
| CN-85105655-A | Process for preparing novel derivatives of 1-methyl-4, 5-dihydroorotic acid and pharmaceutical compositions thereof | — | 1987-01-28 | — | — | CN | claimed |
| EP-0168042-A2 | Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-15 | — | — | EP | claimed |
| CN-109369779-B | Synthetic method of taltirelin | 江苏诺泰澳赛诺生物制药股份有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-109369779-B | Synthetic method of taltirelin | 江苏诺泰澳赛诺生物制药股份有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-109369779-A | A kind of synthetic method of Taltirelin | 江苏诺泰澳赛诺生物制药股份有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-102002004-A | Taltirelin intermediate and synchronizing method of taltirelin | SHENZHEN HYBIO PHARMACEUTICAL | 2011-04-06 | — | — | CN | disclosed |
| US-20080249292-A1 | Plant dihydroorotase | EHRHARDT THOMAS | 2008-10-09 | — | — | US | disclosed |
| CN-1020457-C | Process for preparing novel derivatives of 1-methyl-4, 5-dihydroorotic acid and pharmaceutical compositions thereof | TANABE SEIYAKU CO (JP) | 1993-05-05 | — | — | CN | disclosed |
| CN-1020457-C | Process for preparing novel derivatives of 1-methyl-4, 5-dihydroorotic acid and pharmaceutical compositions thereof | TANABE SEIYAKU CO (JP) | 1993-05-05 | — | — | CN | disclosed |
| US-4665056-A | CENTRAL NERVOUS SYSTEM DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1987-05-12 | — | — | US | disclosed |
| CN-85105655-A | Process for preparing novel derivatives of 1-methyl-4, 5-dihydroorotic acid and pharmaceutical compositions thereof | — | 1987-01-28 | — | — | CN | disclosed |
| CN-85105655-A | Process for preparing novel derivatives of 1-methyl-4, 5-dihydroorotic acid and pharmaceutical compositions thereof | — | 1987-01-28 | — | — | CN | disclosed |
| EP-0168042-A2 | Dihydroorotic acid derivatives, processes for their preparing and pharmaceutical composition containing them | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |