Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352914 | 0.94 | MAOA (0.54) | MAOALOXL2MAOBHTR2ACYP2A6 | |
| SCHEMBL3288071 | 0.81 | MAOB (0.62) | MAOALOXL2MAOBHTR2ACYP2A6 | |
| SCHEMBL1289581 | 0.80 | MAOB (0.48) | MAOAMAOBHTR2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL6558298 | 0.79 | MAOB (0.43) | MAOALOXL2MAOBHTR2ACYP2A6 | |
| SCHEMBL4556291 | 0.78 | MAOB (0.46) | MAOBSMN1; SMN2TOP1POLB | |
| SCHEMBL2261671 | 0.78 | MAOB (0.46) | MAOALOXL2MAOBSIGMAR1TOP1 | |
| SCHEMBL482781 | 0.78 | MAOB (0.46) | MAOBSMN1; SMN2SIGMAR1TOP1 | |
| SCHEMBL18315425 | 0.77 | MAOB (0.44) | MAOBSMN1; SMN2TOP1POLB | |
| SCHEMBL6682937 | 0.77 | SIGMAR1 (0.50) | MAOAMAOBSIGMAR1 | |
| SCHEMBL2761679 | 0.77 | KCNH2 (0.46) | MAOBSMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181279-A4 | DIKETODIAZACYCLIC COMPOUNDS, DIAZACYCLIC COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | TORREY PINES INST (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1181279-A1 | DIKETODIAZACYCLIC COMPOUNDS, DIAZACYCLIC COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000069830-A1 | DIKETODIAZACYCLIC COMPOUNDS, DIAZACYCLIC COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 2000-11-23 | — | — | WO | disclosed |
| EP-0722436-A4 | MERCAPTOSULFIDE METALLOPROTEINASE INHIBITORS | UNIV FLORIDA STATE (US) | 1996-11-20 | — | — | EP | disclosed |
| EP-0722436-A1 | MERCAPTOSULFIDE METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009833-A1 | MERCAPTOSULFIDE METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1995-04-13 | — | — | WO | disclosed |
| EP-0090362-A2 | Derivatives of cycloalka(c)pyrrole-carboxylic acids, process for their preparation, agents containing them and their use, as well as cycloalka(c)pyrrole-carboxylic acids as intermediates, and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-10-05 | — | — | EP | disclosed |