Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 10/20 | 0.41 |
| ▸ | CA12 | O43570 | 7/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 10/20 | 0.41 |
| ▸ | CA9 | Q16790 | 6/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369001 | 0.88 | CA2 (0.41) | SYKCA1CA12CA2CA9 | |
| SCHEMBL7376187 | 0.81 | SYK (0.43) | SYKCA1CA12CA7CA14 | |
| SCHEMBL29879918 | 0.79 | SYK (0.65) | SYKCA1CA12CA7CA14 | |
| SCHEMBL17878732 | 0.79 | SYK (0.65) | SYKCA1CA12CA7CA14 | |
| SCHEMBL27403623 | 0.76 | ABCB1 (0.45) | CA1CA12CA7CA14CA2 | |
| SCHEMBL7365846 | 0.76 | MEN1 (0.36) | SYKCA1CA12CA7CA14 | |
| SCHEMBL27711551 | 0.75 | MEN1 (0.45) | SYKCA1CA12CA7CA14 | |
| SCHEMBL27403629 | 0.75 | CA2 (0.43) | CA1CA12CA2CA9MALT1 | |
| SCHEMBL1822826 | 0.75 | SYK (0.43) | SYKCA1CA12CA7CA14 | |
| SCHEMBL2367757 | 0.75 | SYK (0.60) | SYKCA1CA12CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049693-A1 | 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS $g(a) v?$g(b) 3? ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999026945-A1 | 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS αvβ3 ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |