Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25594538 | 0.91 | CYP2C9 (0.45) | TAS1R3TAS1R1TAS1R2CYP2C9CA12 | |
| SCHEMBL25733769 | 0.84 | TAS1R3 (0.44) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL25719639 | 0.82 | TAS1R3 (0.43) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL11892766 | 0.82 | LMNA (0.53) | TAS1R3TAS1R1TAS1R2CYP2C9CA12 | |
| SCHEMBL27398064 | 0.81 | TAS1R3 (0.42) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL17506705 | 0.81 | TAS1R3 (0.47) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL13888611 | 0.81 | TAS1R3 (0.47) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL13316545 | 0.78 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL25994819 | 0.78 | TAS1R3 (0.45) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL10063637 | 0.77 | PSMB5 (0.45) | TAS1R3TAS1R1TAS1R2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154519-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |
| WO-2022087634-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS CLOTHO, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |