Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KIF5B | P33176 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL622498 | 0.76 | KDM4E (0.49) | KDM4EMEN1LMNAKMT2AMAPT | |
| Bromide SCHEMBL7367912 | 0.75 | KDM4E (0.47) | KDM4EMEN1LMNAKMT2AMAPT | |
| SCHEMBL5212965 | 0.73 | NQO2 (0.40) | NQO2EGFRALOX5APFEN1KDM4E | |
| SCHEMBL3605495 | 0.72 | KMT2A (0.41) | EGFRKDM4EMEN1LMNAKMT2A | |
| SCHEMBL7690476 | 0.70 | NQO2 (0.50) | NQO2HSD17B10KDM4EMEN1LMNA | |
| SCHEMBL31552048 | 0.68 | MAOA (0.44) | EGFRALOX5APFEN1MAPTPDGFRB | |
| SCHEMBL2172807 | 0.67 | KMT2A (0.37) | NQO2EGFRKDRALOX5APFEN1 | |
| SCHEMBL31083509 | 0.67 | NSD2 (0.46) | NQO2KDM4EMEN1KMT2AMAPT | |
| SCHEMBL20576006 | 0.66 | RHEB (0.36) | ALOX5APFEN1CA2CA4ALDH1A1 | |
| SCHEMBL17875684 | 0.65 | HSD17B10 (0.50) | NQO2HSD17B10MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |